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Andro
05-25-2013, 10:22 AM
I have no idea if it's just another hype or an actual game changer in correctly delivered supplementation.

From the source (http://www.huffingtonpost.com/dr-mark-hyman/glutathione-the-mother-of_b_530494.html) - Huffington Post (http://www.huffingtonpost.com/dr-mark-hyman/glutathione-the-mother-of_b_530494.html):

Glutathione: The Mother of All Antioxidants

by Mark Hyman, M.D.

It's the most important molecule you need to stay healthy and prevent disease -- yet you've probably never heard of it. It's the secret to prevent aging, cancer, heart disease, dementia and more, and necessary to treat everything from autism to Alzheimer's disease. There are more than 89,000 medical articles about it -- but your doctor doesn't know how address the epidemic deficiency of this critical life-giving molecule...

What is it? I'm talking about the mother of all antioxidants, the master detoxifier and maestro of the immune system: GLUTATHIONE (pronounced "gloota-thigh-own").

The good news is that your body produces its own Glutathione. The bad news is that poor diet, pollution, toxins, medications, stress, trauma, aging, infections and radiation all deplete your Glutathione.

This leaves you susceptible to unrestrained cell disintegration from oxidative stress, free radicals, infections and cancer. And your liver gets overloaded and damaged, making it unable to do its job of detoxification.

In treating chronically ill patients with Functional Medicine for more than 10 years, I have discovered that Glutathione deficiency is found in nearly all very ill patients. These include people with chronic fatigue syndrome, heart disease, cancer, chronic infections, autoimmune disease, diabetes, autism, Alzheimer's disease, Parkinson's disease, arthritis, asthma, kidney problems, liver disease and more.

At first I thought that this was just a coincidental finding, but over the years I have come to realize that our ability to produce and maintain a high level of Glutathione is critical to recovery from nearly all chronic illness -- and to preventing disease and maintaining optimal health and performance. The authors of those 76,000 medical articles on Glutathione I mentioned earlier have found the same thing!

So in today's blog I want to explain what Glutathione is, why it's important and give you 9 tips that will help you optimize your Glutathione levels, improve your detoxification system and protect help yourself from chronic illness.

What is Glutathione?

Glutathione is a very simple molecule that is produced naturally all the time in your body. It is a combination of three simple building blocks of protein or amino acids -- cysteine, glycine and glutamine.

The secret of its power is the sulfur (SH) chemical groups it contains. Sulfur is a sticky, smelly molecule. It acts like fly paper and all the bad things in the body stick onto it, including free radicals and toxins like mercury and other heavy metals.
Normally glutathione is recycled in the body -- except when the toxic load becomes too great. And that explains why we are in such trouble...
In my practice, I test the genes involved in Glutathione metabolism. These are the genes involved in producing enzymes that allow the body to create and recycle Glutathione in the body. These genes have many names, such as GSTM1, GSTP1 and more.

These genes impaired in some people for a variety of important reasons. We humans evolved in a time before the 80,000 toxic industrial chemicals found in our environment today were introduced into our world, before electromagnetic radiation was everywhere and before we polluted our skies, lakes, rivers, oceans and teeth with mercury and lead.

That is why most people survived with the basic version of the genetic detoxification software encoded in our DNA, which is mediocre at ridding the body of toxins. At the time humans evolved we just didn't need more. Who knew we would be poisoning ourselves and eating a processed, nutrient-depleted diet thousands of years later?

Because most of us didn't require additional detoxification software, almost of half of the population now has a limited capacity to get rid of toxins. These people are missing GSTM1 function -- one of the most important genes needed in the process of creating and recycling Glutathione in the body.

Nearly all my very sick patients are missing this function. The one-third of our population that suffers from chronic disease is missing this essential gene. That includes me. Twenty years ago I became mercury poisoned and suffered from chronic fatigue syndrome due to this very problem. My GSTM1 function was inadequate and I didn't produce enough Glutathione as a result. Eventually, my body broke down and I became extremely ill. This is the same problem I see in so many of my patients. They are missing this critical gene and they descend into disease as a result. Let me explain how this happens ...

The Importance of Glutathione in Protecting Against Chronic Illness

Glutathione is critical for one simple reason: It recycles antioxidants. You see, dealing with free radicals is like handing off a hot potato. They get passed around from vitamin C to vitamin E to lipoic acid and then finally to glutathione which cools off the free radicals and recycles other antioxidants. After this happens, the body can "reduce" or regenerate another protective Glutathione molecule and we are back in business.

However, problems occur when we are overwhelmed with too much oxidative stress or too many toxins. Then the Glutathione becomes depleted and we can no longer protect ourselves against free radicals, infections, or cancer and we can't get rid of toxins. This leads to further sickness and soon we are in the downward spiral of chronic illness.

But that's not all. Glutathione is also critical in helping your immune system do its job of fighting infections and preventing cancer. That's why studies show that it can help in the treatment of AIDS.

Glutathione is also the most critical and integral part of your detoxification system. All the toxins stick onto glutathione, which then carries them into the bile and the stool -- and out of your body.

And lastly, it also helps us reach peak mental and physical function. Research has shown that raised glutathione levels decrease muscle damage, reduce recovery time, increase strength and endurance and shift metabolism from fat production to muscle development.
If you are sick or old or are just not in peak shape, you likely have Glutathione deficiency.
In fact, the top British medical journal, the Lancet, found the highest Glutathione levels in healthy young people, lower levels in healthy elderly, lower still in sick elderly and the lowest of all in the hospitalized elderly.

Keeping yourself healthy, boosting your performance, preventing disease and aging well depends on keeping your Glutathione levels high. I'll say it again... Glutathione is so important because it is responsible for keeping so many of the keys to UltraWellness optimized.
It is critical for immune function and controlling inflammation. It is the master detoxifier and the body's main antioxidant, protecting our cells and making our energy metabolism run well.
And the good news is that you can do many things to increase this natural and critical molecule in your body. You can eat Glutathione-boosting foods. You can exercise. And you can take glutathione-boosting supplements. Let's review more specifics about each.

9 Tips to Optimize your Glutathione Levels

These 9 tips will help you improve your glutathione levels, improve your health, optimize your performance and live a long, healthy life.

Eat Foods that Support Glutathione Production

1. Consume sulfur-rich foods. The main ones in the diet are garlic, onions and the cruciferous vegetables (broccoli, kale, collards, cabbage, cauliflower, watercress, etc.).

2. Try bioactive whey protein. This is great source of cysteine and the amino acid building blocks for glutathione synthesis. As you know, I am not a big fan of dairy. But this is an exception -- with a few warnings. The whey protein MUST be bioactive and made from non-denatured proteins ("denaturing" refers to the breakdown of the normal protein structure). Choose non-pasteurized and non-industrially produced milk that contains no pesticides, hormones, or antibiotics. Immunocal is a prescription bioactive non-denatured whey protein that is even listed in the Physician's Desk Reference.

Exercise for Your Way to More Glutathione

3. Exercise boosts your glutathione levels and thereby helps boost your immune system, improve detoxification and enhance your body's own antioxidant defenses. Start slow and build up to 30 minutes a day of vigorous aerobic exercise like walking or jogging, or play various sports. Strength training for 20 minutes 3 times a week is also helpful.

Take Glutathione Supporting Supplements

One would think it would be easy just to take Glutathione as a pill, but the body digests protein -- so you wouldn't get the benefits if you did it this way. However, the production and recycling of Glutathione in the body requires many different nutrients and you CAN take these. Here are the main supplements that need to be taken consistently to boost Glutathione. Besides taking a multivitamin and fish oil, supporting my Glutathione levels with these supplements is the most important thing I do every day for my personal health.

4. N-acetyl-cysteine. This has been used for years to help treat asthma and lung disease and to treat people with life-threatening liver failure from Tylenol overdose. In fact, I first learned about it in medical school while working in the emergency room. It is even given to prevent kidney damage from dyes used during x-ray studies.

5. Alpha lipoic acid. This is a close second to Glutathione in importance in our cells and is involved in energy production, blood sugar control, brain health and detoxification. The body usually makes it, but given all the stresses we are under, we often become depleted.

6. Methylation nutrients (folate and vitamins B6 and B12). These are perhaps the most critical to keep the body producing glutathione. Methylation and the production and recycling of glutathione are the two most important biochemical functions in your body. Take folate (especially in the active form of 5 methyltetrahydrofolate), B6 (in active form of P5P) and B12 (in the active form of methylcobalamin).

7. Selenium. This important mineral helps the body recycle and produce more Glutathione.

8. A family of antioxidants including vitamins C and E (in the form of mixed tocopherols), work together to recycle Glutathione.

9. Milk thistle (silymarin) has long been used in liver disease and helps boost glutathione levels.

So use these nine tips and see how they work to help you optimzie your glutathione levels. When you do, you will take one more step to lifelong vibrant health.
Now I'd like to hear from you...
Had you ever heard of this important nutrient before?
Have you tried any of the advice in this article?
What effects have you noticed on your health?
Please leave your thoughts by adding a comment below.
To your good health,

Mark Hyman, M.D.
__________________________________

You can Search YouTube for Glutathione (http://www.youtube.com/results?search_query=Glutathione&oq=Glutathione&gs_l=youtube.12..0l10.4010178.4010178.0.4029413.1. 1.0.0.0.0.357.357.3-1.1.0...0.0...1ac.2.11.youtube.GsST4LVrRRw), like the video below (which is basically the same as the text above), but you are also likely to find quite a bit of commercial videos. I'm just passing on what I found...


http://www.youtube.com/watch?v=Eh2PYQBICWs

Ilos
05-25-2013, 03:05 PM
Hey,
This is something that I'm aware of my wealth being, its typically thees kind of molecules and anti bodies that I think are relate with our consciousness
and they all need a bit of our Subconscious power in order for our organism to heal and protect on its own.

Ajnavajra
12-26-2013, 04:47 AM
http://articles.mercola.com/sites/articles/archive/2010/04/10/can-you-use-food-to-increase-glutathione-instead-of-supplements.aspx

III
12-27-2013, 07:13 AM
Glutathione, or glutathione precursors, especially NAC, when had in excess on a regular basis, and I am sorry it isn't any more exact than that, frequently called "glutathione detox" or "NAC detox". This so-called detox is something called "methyltrap" which produces severe folate deficiency symptoms because it flushes all the active b12 from the body in hours in the form of glutathionylcobalamin. It can cause neurological damage starting in weeks call Sub Acute Combined Degeneration. One researcher I have spoken with called it "too dangerous to take in any way". Taking it was probably one of the several worst choices I have made in my life.

Andro
12-27-2013, 07:56 AM
Glutathione, or glutathione precursors, especially NAC, when had in excess on a regular basis, and I am sorry it isn't any more exact than that, frequently called "glutathione detox" or "NAC detox". This so-called detox is something called "methyltrap" which produces severe folate deficiency symptoms because it flushes all the active b12 from the body in hours in the form of glutathionylcobalamin. It can cause neurological damage starting in weeks call Sub Acute Combined Degeneration. One researcher I have spoken with called it "too dangerous to take in any way". Taking it was probably one of the several worst choices I have made in my life.

Interestingly, the article also mentions B12 among the Glutathione precursors:


6. Methylation nutrients (folate and vitamins B6 and B12). These are perhaps the most critical to keep the body producing glutathione. Methylation and the production and recycling of glutathione are the two most important biochemical functions in your body. Take folate (especially in the active form of 5 methyltetrahydrofolate), B6 (in active form of P5P) and B12 (in the active form of methylcobalamin).

III
12-28-2013, 01:20 AM
Interestingly, the article also mentions B12 among the Glutathione precursors:



Yes, As MeCbl is involved in creating glutathione, so are many vitamins. The catch is that it does not promote the production of glutathione to the level that glutathione destroys MeCbl itself. It is self limiting. NAC can over produce as can NAC plus l-glutamate. Direct glutathione itself in any form can of course be too much. And un-denatured whey had the same effect on those trying that approach. Again, it takes relatively large amounts on a frequent basis. 1 mg of glutathione can destroy all the active MeCbl and AdoCbl a person has in their body. So when a person is taking large numbers of mgs daily they are poisoning themselves. MeCbl and AdoCbl act essentially as catalysts. They are the same after the reaction cycle as before. Glutathione literally poisons them. If a person is taking injectable size doses it colors the urine. If a person is injecting 10mg a day, it produces a barely visible pink/ With glutathione, the coloration is like injecting 100mg or more of b12. One can literally see it pour out of the body in a matter of hours.

Andro
12-28-2013, 02:16 AM
Thanks III,

I wonder if the MD who wrote the article had any clue about this in the first place... Apparently not...

III
12-28-2013, 06:07 AM
Thanks III,

I wonder if the MD who wrote the article had any clue about this in the first place... Apparently not...

Hi Androgynus,
One has to read between the lines to find it. The people who typically use it believe in "detox" theory. The research done is based on micro-biochemical studies of what glutathione in natural amounts does in natural functioning. They are not asking the right questions. Who ever digs into "side effects"? For instance, Deplin is 100% Metafolin (Merck's patented stable form of l-methylfolate) in doses of 7.5 through 30mg. According to the Deplin FDA studies, "Deplin is normally well tolerated with side effects similar to placebo". However, Cerefolin (Metafolin) with NAC has a load of side effects, the effects of folate deficiency which are exactly the same as glutathione "detox". Of course it never occurred to those studying it that those "side effects" were folate deficiency when the people were taking 5.6mg of Metafolin and 2.5mg of MeCbl (completely wiped out by the glutathione/NAC), those folate deficiency symptoms caused by paradoxical folate deficiency which is a manifestation of methyltrap.

I can easily instruct somebody in how to make that happen. The researchers and the doctors using it have no idea at all about this. This is completely off the radar because they don't even recognize paradoxical folate deficiency in humans or methyltrap in humans. Further they never use injectable b12 in large enough doses of MeCbl and/or AdoCbl to be visible in the urine so the very obvious to all but those who can't see color never happens to them. They don't know how to ask meaningful questions about this.